It’s Vanessa Helsing vs. vampires in post-apocalyptic Seattle.
In the days leading up to "The Rising," Vanessa is attacked and left for dead by an intruder. When Doc discovers anomalies in Vanessa's bloodwork, Axel and the marines come to retrieve the body, only to become marooned in the hospital when all hell breaks loose outside the building.
The hospital's power source is damaged, jeopardizing the protective UV lights. Vanessa and Axel head into Seattle to scavenge parts, leaving the others to fight against the vampires amongst themselves.
Vanessa and Mohamad head into the vampire-controlled streets in search of Vanessa's daughter; Cynthia is found dead at the hospital, and Doc thinks her apparent suicide is actually a deliberate murder; Vanessa is captured by vampires.
Vanessa, now in the clutches of Julius and his vampire brood, is forced to demonstrate her powers; the refugees discover a serial killer among the residents, and plot to wrestle control from Axel.
Vanessa and Susan are chased by mutated feral vampires in the sewers, arriving back at the hospital only after a hostile takeover.
Vanessa and Axel lead the hospital's last stand against a siege by Julius and his vampire soldiers; Dmitri's arrival with his vampire ``Death Squad'' reveals a possible civil war brewing among the two vampire factions.
Axel leads the surviving members of their group towards his old military base for shelter but finds it abandoned and in disrepair. With vampires closing in all around them, Axel decides they need a safer refuge and decides to go underground. Separated from Vanessa and the group, Mohamad tries to catch up while navigating hostile territory.
The group is trapped inside an underground lab for military experiments, and Vanessa discovers that Axel has been hiding a secret about her past; Mohamad befriends a girl who doesn't fear vampires; Rebecca makes a calculated play.
Still reeling from the dire events of 'The Farm', Vanessa and the group find refuge among a band of humans who have bargained with vampires for peace. Their leader, however, appears to be hiding a terrible secret. Meanwhile, the true serial killer among Vanessa's group is finally revealed.
Vanessa and the group take shelter in Susan's family farm, where drastic action is taken against Sam; Rebecca's latest experiment to create Daywalkers fails, and Dmitri's patience grows thin.
Now in Dmitri and Rebecca's clutches, Vanessa learns secrets from her past and finds herself at a crossroads; Flesh and the Resistance accelerate their timeline to rescue Vanessa; Mohamad and Sheema finally come to blows over their allegiances.
While on the road to a vampire-controlled camp, Vanessa and Mohamad find themselves in a dangerous game of cat-and-mouse against Sam. Sheema discovers a secret that can bring down the ghetto-cell of the Resistance, while Julius takes a clandestine meeting with Dmitri. Ultimately, Vanessa and Mohamad walk into a trap that places one of them in great peril.
Vanessa is once again resurrected and must confront her family's legacy; Axel, Scarlett and the others fend off Blak Tek's forces, who hope to add Scarlett to their list of lab rats.
Vanessa and Mohamad search for Dylan as Dmitri's citadel crumbles around them; Flesh acquires an unexpected ally in one of the Resistance Fighters; Taka clashes with the Vampire Elite.
Vanessa fights to get her daughter out of the citadel; Dmitri and Antanasia hatch a plot to stop Vanessa; Mohamad risks his life to save Vanessa and Dylan.
Vanessa makes a horrific decision to save her daughter; Axel and a former ally struggle to survive in the wild; a group of juvenile delinquents come face to face with a sadistic vampire.
Vanessa encounters a group of vampires whose gruesome methods bring savagery to a new level; the Juvenile Delinquents continue their game of cat and mouse with Sam and that has deadly consequences.
Vanessa faces off against Sam in a bloody showdown; Dmitri hears news that sends him on a warpath after Vanessa; Flesh, Mohamad and Lucky take desperate steps to save their lives.
Vanessa's past rushes back to confront her in an unexpected way; a secret is revealed that Doc has been protecting; in a bid to bolster his power, Dmitri sends Scab on an impossible mission.
Vanessa faces off with Dmitri; Axel fights against becoming a full-fledged vampire; Sam tracks Mohamad, Flesh and Lucky; Scab tries to enlist a fierce group of vampires to join Dmitri.
As the group struggles with the disappearance of one of its own, they accept sanctuary in a town run by its Sheriff and his troops; Dmitri inches closer to achieving his darkest goal.
A tense standoff between law enforcement and the survivors erupts into a bloodbath; in a bid to evade a vicious breed of vampire, Axel and Scarlett find themselves hunted like prey.
A mystery unravels when an organization fighting to find a cure for vampirism enlists the help of someone in the group; old loyalties are put to the test with deadly results.
Sam and Mohamad's shared past comes back to haunt them in more ways than one; at a secluded campsite in the woods, friendships are put through a baptism by fire.
While the rest of the group fight for survival, Axel and Scarlett defend a mountain stronghold against a relentless foe; Doc makes a medical discovery that could change everything.